In a groundbreaking clinical trial, a paralyzed man in Japan has regained the ability to stand independently following an injection of reprogrammed neural stem cells. This first-of-its-kind treatment involved four participants with spinal cord injuries receiving induced pluripotent stem cells (iPSCs) that were converted into neural stem cells.
The procedure marks a significant advancement in regenerative medicine, demonstrating the potential of iPSC-derived therapies for spinal cord injuries. Researchers emphasize the need for further studies to assess the long-term safety and efficacy of this approach. Nonetheless, the trial offers hope for individuals living with paralysis and paves the way for future innovations in stem cell therapy.
Source: Nature
https://www.nature.com/articles/d41586-025-00863-0