In a significant advancement in the fight against antibiotic-resistant bacteria, researchers at McMaster University have identified lariocidin, a novel antibiotic belonging to the lasso peptide family.

This discovery, detailed in the journal Nature, marks the first introduction of a new antibiotic class in nearly three decades. Lariocidin exhibits a unique mode of action by directly binding to bacterial protein synthesis machinery, effectively inhibiting bacterial growth. Notably, it has demonstrated efficacy against drug-resistant strains while exhibiting minimal toxicity to human cells.  

The research team isolated lariocidin from Paenibacillus bacteria found in a Hamilton backyard soil sample. By cultivating these soil bacteria over an extended period, they uncovered slow-growing species capable of producing potent antibacterial substances. 

Lariocidin’s discovery offers promising potential in addressing the escalating global health threat posed by antimicrobial resistance. The team is now focused on modifying the molecule and scaling up production to advance towards clinical development.  

Source: Phys.org

https://phys.org/news/2025-03-breakthrough-moment-class-antibiotics.html